Eliminating drivers of disease with novel LYTAC therapeutics

Lycia is a biotechnology company developing novel therapeutics to eliminate disease-causing extracellular proteins. Our platform is designed to produce specific and potent protein degrading therapeutics, called LYTACs (Lysosomal Targeting Chimeras), that bind the target protein and transport it into the cell for degradation by the lysosome, leveraging the cell’s natural waste disposal process.

Targeted protein degradation is being investigated as an approach to address a variety of disease-causing proteins that had been previously considered undruggable, but these therapies have primarily focused on proteins that exist within the cell. This has left a significant gap in developing therapeutics capable of degrading disease-causing proteins that exist on the cell surface or in circulation. Our LYTAC platform allows us to develop therapeutics that we believe can benefit patients’ lives through its novel method of targeting and degrading these disease-driving proteins.

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Our Scientific Foundation

In July 2020, Carolyn Bertozzi, Ph.D., who received the Nobel Prize in Chemistry in 2022 for founding the field of bioorthogonal chemistry, and her team at Stanford University published a transformational paper that characterized a new class of molecules called lysosome-targeting chimeras, or LYTACs. In the paper, Dr. Bertozzi and her team described a new approach to shuttle a targeted extracellular protein from outside the cell into the lysosome, a cellular component inherently responsible for degradation.

Since then, we have worked to refine the platform technology, expanding the approach to leverage multiple therapeutic modalities and internalizing receptors to shuttle the targeted protein for degradation. These advances have strengthened the therapeutic potential of the LYTAC platform from which we are developing a pipeline of development candidates.

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Prof. Carolyn Bertozzi
Lycia founder and Professor of Chemistry, Stanford University
Investigator, Howard Hughes Medical Institute

Team

Management

Aetna-Wun-Trombley

Aetna Wun Trombley, Ph.D.

President and CEO
Bio »

Aetna Wun Trombley, Ph.D., has served as President, Chief Executive Officer, and a member of Lycia’s board of directors since April 2020. She also served as an independent director of Carmot Therapeutics from 2016 until its acquisition by Roche in 2024. Prior to joining Lycia, Aetna was President and Chief Operating Officer of NGM Biopharmaceuticals, where she had broad strategic and operational responsibilities for nine years. At NGM, she was instrumental in establishing multiple strategic partnerships and a successful initial public offering in 2019. Previously, she served as Chief of Staff for the Chief Executive Officer of Novartis and was a management consultant at McKinsey & Company. She received a B.S. in Chemistry from the University of California, San Diego, and a Ph.D. in Chemistry from MIT.

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Aetna-Wun-Trombley

Aetna Wun Trombley, Ph.D.

President and CEO

Aetna Wun Trombley, Ph.D., has served as President, Chief Executive Officer, and a member of Lycia’s board of directors since April 2020. She also served as an independent director of Carmot Therapeutics from 2016 until its acquisition by Roche in 2024. Prior to joining Lycia, Aetna was President and Chief Operating Officer of NGM Biopharmaceuticals, where she had broad strategic and operational responsibilities for nine years. At NGM, she was instrumental in establishing multiple strategic partnerships and a successful initial public offering in 2019. Previously, she served as Chief of Staff for the Chief Executive Officer of Novartis and was a management consultant at McKinsey & Company. She received a B.S. in Chemistry from the University of California, San Diego, and a Ph.D. in Chemistry from MIT.

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Steve-Staben

Steve Staben, Ph.D.

Chief Scientific Officer
Bio »

Steve Staben, Ph.D., joined Lycia Therapeutics as Chief Scientific Officer in October 2021. Prior to Lycia, he spent over 14 years at Genentech, leading drug discovery programs in oncology and immunology as well as new modality platforms. His basic research interests include new mechanisms for the modulation of therapeutic targets, including applications of induced proximity. He has co-authored over 70 peer-reviewed articles and patent applications. Steve holds his Ph.D. in Organic Chemistry from the University of California, Berkeley.

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Steve-Staben

Steve Staben, Ph.D.

Chief Scientific Officer

Steve Staben, Ph.D., joined Lycia Therapeutics as Chief Scientific Officer in October 2021. Prior to Lycia, he spent over 14 years at Genentech, leading drug discovery programs in oncology and immunology as well as new modality platforms. His basic research interests include new mechanisms for the modulation of therapeutic targets, including applications of induced proximity. He has co-authored over 70 peer-reviewed articles and patent applications. Steve holds his Ph.D. in Organic Chemistry from the University of California, Berkeley.

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Sofia-Touami

Sofia Touami, Ph.D.

Chief Business Officer
Bio »

Sofia Touami, Ph.D., joined Lycia as Chief Business Officer in July 2023. Prior to Lycia, she was Chief Business Officer at Hexagon Bio, responsible for strategic planning, business development, and corporate operations. Previously, she served as Vice President of Business Development at Frontier Medicines, where she led business operations and transactions, including the company’s global strategic collaboration with AbbVie. Before joining Frontier, Sofia was Senior Director of Business Development and Alliance Management at NGM Biopharmaceuticals, where she negotiated and managed multiple partnerships with academic, non-profit, and industry partners. Sofia received an A.B. in Chemistry from Washington University in St. Louis, a Ph.D. in Organic Chemistry from Stanford University, and completed postdoctoral studies at The Scripps Research Institute.

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Sofia-Touami

Sofia Touami, Ph.D.

Chief Business Officer

Sofia Touami, Ph.D., joined Lycia as Chief Business Officer in July 2023. Prior to Lycia, she was Chief Business Officer at Hexagon Bio, responsible for strategic planning, business development, and corporate operations. Previously, she served as Vice President of Business Development at Frontier Medicines, where she led business operations and transactions, including the company’s global strategic collaboration with AbbVie. Before joining Frontier, Sofia was Senior Director of Business Development and Alliance Management at NGM Biopharmaceuticals, where she negotiated and managed multiple partnerships with academic, non-profit, and industry partners. Sofia received an A.B. in Chemistry from Washington University in St. Louis, a Ph.D. in Organic Chemistry from Stanford University, and completed postdoctoral studies at The Scripps Research Institute.

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Jian-Cao

Jian Cao, Ph.D., RAC

Vice President, Head of CMC
Bio »

Jian Cao, Ph.D., serves as Vice President of Chemistry, Manufacturing and Controls (CMC). Prior to Lycia, he served as Vice President of Pharmaceutical Development at Invectys, Inc., a clinical-stage immuno-oncology company where he led all CMC and IND-enabling studies on CAR-T cell therapy, monoclonal antibody, nanobody, and DNA cancer vaccine development. Before joining Invectys, Jian was the Acting General Manager for Alvotech & CCHT Biopharmaceuticals Inc., where he led cGMP manufacturing including process development, manufacturing, QA, QC, regulatory affairs, preclinical, and clinical development. Prior to that, he worked at Sorrento Therapeutics and was responsible for multiple antibody drug development programs. Jian received his B.S. in Applied Chemistry and his M.S. in Polymer Chemistry from Jilin University in Changchun, China. He received his Ph.D. in Protein Biochemistry from the University of New Mexico and completed his postdoctoral studies at the University of California, San Diego.

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Jian-Cao

Jian Cao, Ph.D., RAC

Vice President, Head of CMC

Jian Cao, Ph.D., serves as Vice President of Chemistry, Manufacturing and Controls (CMC). Prior to Lycia, he served as Vice President of Pharmaceutical Development at Invectys, Inc., a clinical-stage immuno-oncology company where he led all CMC and IND-enabling studies on CAR-T cell therapy, monoclonal antibody, nanobody, and DNA cancer vaccine development. Before joining Invectys, Jian was the Acting General Manager for Alvotech & CCHT Biopharmaceuticals Inc., where he led cGMP manufacturing including process development, manufacturing, QA, QC, regulatory affairs, preclinical, and clinical development. Prior to that, he worked at Sorrento Therapeutics and was responsible for multiple antibody drug development programs. Jian received his B.S. in Applied Chemistry and his M.S. in Polymer Chemistry from Jilin University in Changchun, China. He received his Ph.D. in Protein Biochemistry from the University of New Mexico and completed his postdoctoral studies at the University of California, San Diego.

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Winsome-Chung

Winsome Chung

Vice President, Head of Finance
Bio »

Winsome Chung joined Lycia Therapeutics as Vice President, Finance in May 2022. She has over 20 years of finance, accounting and business operations experience in private and publicly-traded companies across multiple industries including early- to late-stage life science companies. Before joining Lycia, she served as Head of Financial Planning and Analysis at ArsenalBio where she led the corporate and strategic planning function. Prior to ArsenalBio, Winsome held multiple roles at NGM Biopharmaceuticals where she served as Controller as well as Executive Director of FP&A. During her tenure there, she built out and scaled the accounting and finance functions and supported the company’s initial public offering. Winsome holds a B.S. in Business Administration from the University of California, Berkeley.

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Winsome-Chung

Winsome Chung

Vice President, Head of Finance

Winsome Chung joined Lycia Therapeutics as Vice President, Finance in May 2022. She has over 20 years of finance, accounting and business operations experience in private and publicly-traded companies across multiple industries including early- to late-stage life science companies. Before joining Lycia, she served as Head of Financial Planning and Analysis at ArsenalBio where she led the corporate and strategic planning function. Prior to ArsenalBio, Winsome held multiple roles at NGM Biopharmaceuticals where she served as Controller as well as Executive Director of FP&A. During her tenure there, she built out and scaled the accounting and finance functions and supported the company’s initial public offering. Winsome holds a B.S. in Business Administration from the University of California, Berkeley.

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Darrin-Lindhout

Darrin Lindhout, Ph.D.

Executive Director, Head of Biologics
Bio »

Darrin Lindhout, Ph.D. joined Lycia in September 2020 and is Lycia’s Executive Director, Head of Biologics, providing leadership for biologics and discovery research efforts. He was most recently Director, Protein Sciences at NGM Biopharmaceuticals, where he spent over 11 years building their biologics capabilities. While at NGM, he directly contributed to seven IND candidates and was involved in protein engineering and research processes spanning metabolic, oncology, and ophthalmology indications, resulting in more than 20 granted patents pertaining to protein structure/function. Prior to NGM, Darrin completed his postdoctoral research at Stanford University School of Medicine in the Department of Structural Biology in 2008 and received his Ph.D. in Biochemistry from the Department of Biochemistry at the University of Alberta in 2005.

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Darrin-Lindhout

Darrin Lindhout, Ph.D.

Executive Director, Head of Biologics

Darrin Lindhout, Ph.D. joined Lycia in September 2020 and is Lycia’s Executive Director, Head of Biologics, providing leadership for biologics and discovery research efforts. He was most recently Director, Protein Sciences at NGM Biopharmaceuticals, where he spent over 11 years building their biologics capabilities. While at NGM, he directly contributed to seven IND candidates and was involved in protein engineering and research processes spanning metabolic, oncology, and ophthalmology indications, resulting in more than 20 granted patents pertaining to protein structure/function. Prior to NGM, Darrin completed his postdoctoral research at Stanford University School of Medicine in the Department of Structural Biology in 2008 and received his Ph.D. in Biochemistry from the Department of Biochemistry at the University of Alberta in 2005.

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Sarah-McWhirter

Sarah McWhirter, Ph.D.

Vice President, Head of Biology
Bio »

Sarah McWhirter, Ph.D. serves as Vice President, Head of Biology at Lycia Therapeutics. Prior to Lycia, she served as Executive Director of Research and Translational Medicine at Aduro Biotech. At Aduro, Sarah was promoted into roles of increasing responsibility where she was the primary R&D lead for the Novartis partnership developing STING agonists for oncology that led to a first-in-human STING agonist. She and her team also spearheaded discovery efforts that enabled a research collaboration and licensing agreement with Eli Lilly to develop therapeutics for autoimmune and inflammatory diseases. Prior to Aduro, Sarah supervised research activities in Dr. Mark Schlissel’s laboratory at the University of California, Berkeley. Sarah earned her Ph.D. in Molecular and Cell Biology from the University of California, Berkeley, and conducted a postdoctoral fellowship at Harvard University in the laboratory of Dr. Tom Maniatis.

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Sarah-McWhirter

Sarah McWhirter, Ph.D.

Vice President, Head of Biology

Sarah McWhirter, Ph.D. serves as Vice President, Head of Biology at Lycia Therapeutics. Prior to Lycia, she served as Executive Director of Research and Translational Medicine at Aduro Biotech. At Aduro, Sarah was promoted into roles of increasing responsibility where she was the primary R&D lead for the Novartis partnership developing STING agonists for oncology that led to a first-in-human STING agonist. She and her team also spearheaded discovery efforts that enabled a research collaboration and licensing agreement with Eli Lilly to develop therapeutics for autoimmune and inflammatory diseases. Prior to Aduro, Sarah supervised research activities in Dr. Mark Schlissel’s laboratory at the University of California, Berkeley. Sarah earned her Ph.D. in Molecular and Cell Biology from the University of California, Berkeley, and conducted a postdoctoral fellowship at Harvard University in the laboratory of Dr. Tom Maniatis.

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Larry Rozsnyai, Ph.D.

Vice President, Head of Intellectual Property
Bio »

Larry Rozsnyai, Ph.D., serves as Vice President of Intellectual Property. Prior to Lycia, he served as Vice President of IP, Licensing and Transactions at Olema Pharmaceuticals, Vice President of IP at Myovant Sciences, and Senior Counsel, Intellectual Property at Gilead. Larry has built patent portfolios supporting multiple commercial products, defended patents from third-party oppositions in Europe, India, and other countries, negotiated and closed research and commercial license agreements, and led other strategic initiatives. Larry received his B.S. in Chemistry from the University of California, Berkeley, his Ph.D. in Chemistry from the Massachusetts Institute of Technology, performed postdoctoral research at Harvard University, and received his J.D. from the University of Washington.

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larry-rozsnyai

Larry Rozsnyai, Ph.D.

Vice President, Head of Intellectual Property

Larry Rozsnyai, Ph.D., serves as Vice President of Intellectual Property. Prior to Lycia, he served as Vice President of IP, Licensing and Transactions at Olema Pharmaceuticals, Vice President of IP at Myovant Sciences, and Senior Counsel, Intellectual Property at Gilead. Larry has built patent portfolios supporting multiple commercial products, defended patents from third-party oppositions in Europe, India, and other countries, negotiated and closed research and commercial license agreements, and led other strategic initiatives. Larry received his B.S. in Chemistry from the University of California, Berkeley, his Ph.D. in Chemistry from the Massachusetts Institute of Technology, performed postdoctoral research at Harvard University, and received his J.D. from the University of Washington.

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Nadia-Tchao

Nadia Tchao, M.D.

Executive Director, Head of Translational Medicine/Early Development
Bio »

Nadia Tchao, M.D. serves as Executive Director, Head of Translational Medicine/Early Development at Lycia. Nadia has over 17 years of experience leading cross-functional teams to develop innovative clinical development strategies for new drug candidates across a broad range of inflammation indications. She has worked across diverse therapeutic modalities and served as the translational medicine representative on targets from early-stage research to late-stage development. Most recently, she was a Medical Director of Early Development, Inflammation at Amgen for over seven years, during which time she led the development of multiple early assets from IND filing through proof-of-concept studies. Nadia earned a BS in Molecular Biology from the University of California, Berkeley, and an M.D. from Duke University. She completed her Internship and Residency in Internal Medicine at the University of Pennsylvania and a Pulmonary Critical Care Fellowship at the University of California San Francisco, where she was an Associate Professor prior to joining industry.

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Nadia-Tchao

Nadia Tchao, M.D.

Executive Director, Head of Translational Medicine/Early Development

Nadia Tchao, M.D. serves as Executive Director, Head of Translational Medicine/Early Development at Lycia. Nadia has over 17 years of experience leading cross-functional teams to develop innovative clinical development strategies for new drug candidates across a broad range of inflammation indications. She has worked across diverse therapeutic modalities and served as the translational medicine representative on targets from early-stage research to late-stage development. Most recently, she was a Medical Director of Early Development, Inflammation at Amgen for over seven years, during which time she led the development of multiple early assets from IND filing through proof-of-concept studies. Nadia earned a BS in Molecular Biology from the University of California, Berkeley, and an M.D. from Duke University. She completed her Internship and Residency in Internal Medicine at the University of Pennsylvania and a Pulmonary Critical Care Fellowship at the University of California San Francisco, where she was an Associate Professor prior to joining industry.

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jay-tibbits

Jay Tibbitts, D.V.M., Ph.D.

Vice President, Head of Nonclinical Development
Bio »

Jay Tibbitts joined Lycia Therapeutics as Head of Nonclinical Development in October 2024. Prior to joining Lycia, he led Nonclinical PKPD organizations at Abbvie, UCB, and Genentech and led Nonclinical Development at Surrozen, Inc. As Project Leader, Jay successfully guided Surrozen’s lead program, SZN-043, into clinical development. Jay has dedicated much of his career to the quantitative pharmacology and development of both small and large molecule drugs across multiple indications; and has contributed to the filing of more than 20 INDs and several BLAs. Jay received his Ph.D. in pharmaceutical chemistry from the University of California, San Francisco and a D.V.M. from Ohio State University.

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jay-tibbits

Jay Tibbitts, D.V.M., Ph.D.

Vice President, Head of Nonclinical Development

Jay Tibbitts joined Lycia Therapeutics as Head of Nonclinical Development in October 2024. Prior to joining Lycia, he led Nonclinical PKPD organizations at Abbvie, UCB, and Genentech and led Nonclinical Development at Surrozen, Inc. As Project Leader, Jay successfully guided Surrozen’s lead program, SZN-043, into clinical development. Jay has dedicated much of his career to the quantitative pharmacology and development of both small and large molecule drugs across multiple indications; and has contributed to the filing of more than 20 INDs and several BLAs. Jay received his Ph.D. in pharmaceutical chemistry from the University of California, San Francisco and a D.V.M. from Ohio State University.

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Board of Directors

William J. Rieflin

Chair, Lycia’s Board of Directors
Chair, NGM Biopharmaceuticals
Bio »

William Rieflin became Chair of Lycia’s Board of Directors in December 2020. He is currently Chair of the Board of Directors of NGM Bio after having served as Chief Executive Officer of the company and a member of its Board from September 2010 to September 2018. Prior to joining NGM, he was President of XenoPort, Inc. (NASDAQ: XNPT), which was acquired by Arbor Pharmaceuticals in 2016, and Executive Vice President, Administration, Chief Financial Officer, General Counsel, and Secretary for Tularik Inc. (NASDAQ: TLRK), which was acquired by Amgen Inc. in 2004. Previously, he was Vice President, Human Resources, General Counsel and Secretary for AMSCO International, Inc. (NYSE: ASZ). He was also an associate at Sidley & Austin in the corporate and securities department. In addition to Lycia and NGM, he is currently on the Board of Directors of Kallyope, Inc., Lyell Immunopharma, Inc. (NASDAQ: LYEL) and RAPT Therapeutics, Inc. (NASDAQ: RAPT). William earned his B.S. from Cornell University, his M.B.A. from the University of Chicago Booth School of Business, and his J.D. from Stanford Law School.

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William J. Rieflin

Chair, Lycia’s Board of Directors
Chair, NGM Biopharmaceuticals

William Rieflin became Chair of Lycia’s Board of Directors in December 2020. He is currently Chair of the Board of Directors of NGM Bio after having served as Chief Executive Officer of the company and a member of its Board from September 2010 to September 2018. Prior to joining NGM, he was President of XenoPort, Inc. (NASDAQ: XNPT), which was acquired by Arbor Pharmaceuticals in 2016, and Executive Vice President, Administration, Chief Financial Officer, General Counsel, and Secretary for Tularik Inc. (NASDAQ: TLRK), which was acquired by Amgen Inc. in 2004. Previously, he was Vice President, Human Resources, General Counsel and Secretary for AMSCO International, Inc. (NYSE: ASZ). He was also an associate at Sidley & Austin in the corporate and securities department. In addition to Lycia and NGM, he is currently on the Board of Directors of Kallyope, Inc., Lyell Immunopharma, Inc. (NASDAQ: LYEL) and RAPT Therapeutics, Inc. (NASDAQ: RAPT). William earned his B.S. from Cornell University, his M.B.A. from the University of Chicago Booth School of Business, and his J.D. from Stanford Law School.

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Tim Anderson

Managing Director, Blue Owl
Bio »

Tim Anderson is a Managing Director at Blue Owl and a member of the Healthcare Opportunities Investment Team. In his role, he focuses on investments in biotechnology, diagnostics, and digital medicine companies and sits on the Fund’s Investment Committee. Tim received a BA in both
Economics and Government & Legal studies from Bowdoin College.

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Tim Anderson

Managing Director, Blue Owl

Tim Anderson is a Managing Director at Blue Owl and a member of the Healthcare Opportunities Investment Team. In his role, he focuses on investments in biotechnology, diagnostics, and digital medicine companies and sits on the Fund’s Investment Committee. Tim received a BA in both
Economics and Government & Legal studies from Bowdoin College.

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Ming Fang

Managing Director, Redmile Group
Bio »

Ming is a Managing Director at Redmile Group, LLC, a healthcare-focused investment firm.  Prior to joining Redmile in 2016, Ming worked in the healthcare space as an investor at Safeguard Scientifics, a consultant at McKinsey & Company and ZS Associates, and an operator at Gilead Sciences.  Ming graduated with a B.A. in Computer Science from UC Berkeley and an MBA in Finance and Healthcare Management from the Wharton School of Business.

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Ming Fang

Managing Director, Redmile Group

Ming is a Managing Director at Redmile Group, LLC, a healthcare-focused investment firm.  Prior to joining Redmile in 2016, Ming worked in the healthcare space as an investor at Safeguard Scientifics, a consultant at McKinsey & Company and ZS Associates, and an operator at Gilead Sciences.  Ming graduated with a B.A. in Computer Science from UC Berkeley and an MBA in Finance and Healthcare Management from the Wharton School of Business.

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Laurent Fischer, M.D.

President and Chief Executive Officer, Adverum Biotechnologies
Bio »

Fischer has more than 20 years of drug development and commercialization experience in the biopharmaceutical industry. Before joining Adverum, Dr. Fischer was senior vice president and head of the Liver Therapeutic Area at Allergan, PLC. Previously, he served as chairman and chief executive officer of Tobira Therapeutics until its acquisition by Allergan in November 2016. Previously, he served as chairman and chief executive officer of Jennerex, Inc. until its acquisition by SillaJen Biotherapeutics, Inc. Prior to Jennerex, he was co-founder, president, and chief executive officer of Ocera Therapeutics and president and chief executive officer of Auxeris Therapeutics, Inc. Over the span of his career, Dr. Fischer has held roles of increasing responsibility at several companies, including, RXCentric, Inc. (now part of Allscripts Healthcare Solutions, Inc.), MedVantx Inc., Dupont Pharmaceuticals, Dupont-Merck, and F. Hoffmann-La Roche.

Dr. Fischer earned his undergraduate degree from the University of Geneva and an M.D. from the Geneva Medical School. He currently serves on the boards of directors at Mirum Pharmaceuticals, Inc. and Lycia Therapeutics.

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Laurent Fischer, M.D.

President and Chief Executive Officer, Adverum Biotechnologies

Fischer has more than 20 years of drug development and commercialization experience in the biopharmaceutical industry. Before joining Adverum, Dr. Fischer was senior vice president and head of the Liver Therapeutic Area at Allergan, PLC. Previously, he served as chairman and chief executive officer of Tobira Therapeutics until its acquisition by Allergan in November 2016. Previously, he served as chairman and chief executive officer of Jennerex, Inc. until its acquisition by SillaJen Biotherapeutics, Inc. Prior to Jennerex, he was co-founder, president, and chief executive officer of Ocera Therapeutics and president and chief executive officer of Auxeris Therapeutics, Inc. Over the span of his career, Dr. Fischer has held roles of increasing responsibility at several companies, including, RXCentric, Inc. (now part of Allscripts Healthcare Solutions, Inc.), MedVantx Inc., Dupont Pharmaceuticals, Dupont-Merck, and F. Hoffmann-La Roche.

Dr. Fischer earned his undergraduate degree from the University of Geneva and an M.D. from the Geneva Medical School. He currently serves on the boards of directors at Mirum Pharmaceuticals, Inc. and Lycia Therapeutics.

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Andrew Gottesdiener, M.D.

Partner, Venrock Healthcare Capital Partners
Bio »

Andrew Gottesdiener, M.D., is a partner at Venrock Healthcare Capital Partners in its New York office, where he focuses on healthcare investments. He is also a co-founder of Apogee Therapeutics and has served as a member of its Board of Directors since 2022. Prior to joining Venrock full-time in September 2018, he earned his M.D. at Weill Cornell Medical College, during which he received an HHMI summer fellowship for basic science research. He also has an M.B.A. from Columbia Business School. Andrew received an AB in Economics from Washington University in St. Louis.

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Andrew Gottesdiener, M.D.

Partner, Venrock Healthcare Capital Partners

Andrew Gottesdiener, M.D., is a partner at Venrock Healthcare Capital Partners in its New York office, where he focuses on healthcare investments. He is also a co-founder of Apogee Therapeutics and has served as a member of its Board of Directors since 2022. Prior to joining Venrock full-time in September 2018, he earned his M.D. at Weill Cornell Medical College, during which he received an HHMI summer fellowship for basic science research. He also has an M.B.A. from Columbia Business School. Andrew received an AB in Economics from Washington University in St. Louis.

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Clare Ozawa, Ph.D.

Managing Director, Versant Ventures
Bio »

Clare Ozawa, Ph.D., is a Managing Director at Versant Ventures with a focus on investments in the Bay Area and San Diego. Previously, she was COO of Inception Sciences, where she was responsible for strategic business development, operations and finance for the Inception Sciences research sites in San Diego, Vancouver and Montreal. During her tenure at Inception, she assumed leadership roles in the creation and management of six new companies launched in partnership with academic researchers and major biopharmaceutical companies. Prior to Inception, Clare was an investment professional at Versant, where she was involved in several successful investments, including Flexion (2014 IPO), BioTie (sale) and Quanticel (sale). Earlier in her career, she worked at Novartis Pharma in the Office of the CEO and was at McKinsey & Company. Clare earned her B.S. in biological sciences with honors and distinction from Stanford University, and a Ph.D. in neurosciences from Stanford University Medical School.

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Clare Ozawa, Ph.D.

Managing Director, Versant Ventures

Clare Ozawa, Ph.D., is a Managing Director at Versant Ventures with a focus on investments in the Bay Area and San Diego. Previously, she was COO of Inception Sciences, where she was responsible for strategic business development, operations and finance for the Inception Sciences research sites in San Diego, Vancouver and Montreal. During her tenure at Inception, she assumed leadership roles in the creation and management of six new companies launched in partnership with academic researchers and major biopharmaceutical companies. Prior to Inception, Clare was an investment professional at Versant, where she was involved in several successful investments, including Flexion (2014 IPO), BioTie (sale) and Quanticel (sale). Earlier in her career, she worked at Novartis Pharma in the Office of the CEO and was at McKinsey & Company. Clare earned her B.S. in biological sciences with honors and distinction from Stanford University, and a Ph.D. in neurosciences from Stanford University Medical School.

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Aetna Wun Trombley, Ph.D.

President and CEO
Bio »

Aetna Wun Trombley, Ph.D., has served as President, Chief Executive Officer, and a member of Lycia’s board of directors since April 2020. She also served as an independent director of Carmot Therapeutics from 2016 until its acquisition by Roche in 2024. Prior to joining Lycia, Aetna was President and Chief Operating Officer of NGM Biopharmaceuticals, where she had broad strategic and operational responsibilities for nine years. At NGM, she was instrumental in establishing multiple strategic partnerships and a successful initial public offering in 2019. Previously, she served as Chief of Staff for the Chief Executive Officer of Novartis and was a management consultant at McKinsey & Company. She received a B.S. in Chemistry from the University of California, San Diego, and a Ph.D. in Chemistry from MIT.

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Aetna-Wun-Trombley

Aetna Wun Trombley, Ph.D.

President and CEO

Aetna Wun Trombley, Ph.D., has served as President, Chief Executive Officer, and a member of Lycia’s board of directors since April 2020. She also served as an independent director of Carmot Therapeutics from 2016 until its acquisition by Roche in 2024. Prior to joining Lycia, Aetna was President and Chief Operating Officer of NGM Biopharmaceuticals, where she had broad strategic and operational responsibilities for nine years. At NGM, she was instrumental in establishing multiple strategic partnerships and a successful initial public offering in 2019. Previously, she served as Chief of Staff for the Chief Executive Officer of Novartis and was a management consultant at McKinsey & Company. She received a B.S. in Chemistry from the University of California, San Diego, and a Ph.D. in Chemistry from MIT.

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Scientific Advisory Board

Carolyn Bertozzi, Ph.D.

Professor of Chemistry, Stanford University
Investigator, Howard Hughes Medical Institute
Chair, Lycia Scientific Advisory Board
Bio »
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Carolyn Bertozzi, Ph.D.

Professor of Chemistry, Stanford University
Investigator, Howard Hughes Medical Institute
Chair, Lycia Scientific Advisory Board
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Monther Abu-Remaileh, Ph.D.

Assistant Professor of Chemical Engineering, Stanford University
Bio »
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Monther Abu-Remaileh, Ph.D.

Assistant Professor of Chemical Engineering, Stanford University
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Steven Banik, Ph.D.

Assistant Professor of Chemistry, Stanford University
Bio »
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Steven Banik, Ph.D.

Assistant Professor of Chemistry, Stanford University
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Mark M. Davis, Ph.D.

Professor of Microbiology and Immunology, Stanford University
Investigator, Howard Hughes Medical Institute
Bio »
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Mark M. Davis, Ph.D.

Professor of Microbiology and Immunology, Stanford University
Investigator, Howard Hughes Medical Institute
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Randy Schekman, Ph.D.

Professor of Cell and Developmental Biology, University of California at Berkeley
Investigator, Howard Hughes Medical Institute
Bio »
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Randy Schekman, Ph.D.

Professor of Cell and Developmental Biology, University of California at Berkeley
Investigator, Howard Hughes Medical Institute
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Alanna Schepartz, Ph.D.

Professor of Molecular and Cell Biology, University of California at Berkeley
Bio »
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Alanna Schepartz, Ph.D.

Professor of Molecular and Cell Biology, University of California at Berkeley
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Daniel D. Von Hoff, M.D.

Distinguished Professor at the Translational Genomics Research Institute
Bio »
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Daniel D. Von Hoff, M.D.

Distinguished Professor at the Translational Genomics Research Institute
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Investors

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Partnering with Lycia

The flexibility and modular design of our LYTAC platform enable vast potential to generate high-quality candidates for multiple disease areas in a rapid and efficient manner. To maximize the impact of our work for a broad spectrum of patients, we work with partners to discover and develop new LYTAC therapeutics using the combined forces of scientific and patient insights to guide our joint efforts.

Partnerships in Action

We have an ongoing multi-year research collaboration with Eli Lilly and Company to discover and develop novel targeted protein degraders for up to five targets in areas including immunology and pain.